AM--
I am the first to concede that identifying the exact frame JBC is shot...well, I am guessing.
JBC's mouth gapes open after Z-295, maybe toward Z-300 or later, as if he is in pain.
Humans take more than one-tenth of a second to register pain, generally, or so I have read.
Mrs. Connally's face is somewhat obscured, and, of course, this is a blurry home movie we are watching.
She seems to turn towards JBC after Z-300.
Maybe Dallas Sheriff Seymour Weitzman and SS agent Kellerman were correct: The second two audible shots were in close sequence. They were both familiar with firearms, and seemed to lack any axes to grind.
Just IMHO.